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研究

Bioelectronics meets medicine

Assistant professor Wubin呗 and his team have developed a novel, bioelectronic technology that will improve patients’ lives, helping to safely automate and lower the burden of post-recovery care.

人 standing in a re欧亚体育 实验室.
Members of the Bai team. 后排(从左至右):张琳,刘仪涵,阿俊·普查,白武斌和王仪航. Front row (left to right): Kimberly Brown and Hannah Weisbecker. Image credit: Bai Lab.

当 Wubin呗 他的形成 实验室, he was determined to incorporate and cultivate a culture of col实验室oration. 他是欧亚体育应用物理科学系的助理教授, Bai infuses this approach throughout his work. 他的团队由来自APS和北卡罗来纳大学医学院的多学科研究生和本科生组成,他们的新型无线传感贴片减少了术后组织损伤,正受到人们的关注, while improving user comfort compared with implantable deep-tissue monitors.

“与来自不同背景的研究人员合作,在研究过程中增加了更多的可能性,白说。. “不同的背景可以提供来自不同角度的想法, which can spark important moments.”

The sensing patch is a wearable, wireless patch for deep tissue monitoring of biometric indicators, including heart pulsation and respiration, the amount of oxygen in the blood (pulse oximetry), and the amount of oxygen in body tissues (tissue oximetry). With its wireless capabilities, 该传感贴片允许临床医生远程实时监测患者, which can lead to improved health outcomes.

And because it is wearable, 与植入式监测器相比,传感贴片减少了组织损伤,提高了患者的舒适度,当涉及到深层组织监测的需求时. 此外,贴片可以同时提供局部和全局的生理信息.

欧亚体育认为欧亚体育开发的传感补丁可以为肌肉监测开辟新的机会,白说。, who came to UNC Chapel-Hill in 2021. “传统的可穿戴电子设备可以捕捉脉冲氧合或跟踪步行距离或运动强度. But we wanted to make a device that could capture the local tissue region, especially deep inside the skin instead of just the skin interface. 这种感应贴片可以使那些可能经历过复杂手术或可能有较高感染和炎症几率的患者受益.”

So how does it work? 例如,遭遇不幸的病人有时需要肌肉瓣移植. 在这些情况下, 重建的皮瓣需要临床医生的密切监测,以确保新移植的组织与邻近组织融合. 现有的术后护理策略仅依赖于体格检查和外部多普勒检测——这两种方法都有局限性,因为它们依赖于床边工作人员的技能,他们必须不断检查转移的皮瓣. 然而, 白实验室开发的皮肤界面贴片使用微针波导,克服了与皮肤和脂肪组织相关的光散射和吸收,使医疗提供者能够评估组织深处的健康和愈合.

“传感贴片及其无线同步功能允许持续监测,并可以立即提醒临床人员任何问题. This allows the recovery to become more automated, lowering the burden of post-surgery monitoring or post-surgery care,白说。. “The wireless sensing patch provides a safe, 实时, 一种创伤小、成本低的皮瓣移植手术恢复监测方法.”

Bai的团队最近发表了一篇关于该技术的论文《欧亚体育app注册》 发表 in Advanced Materials Technology. 

“这是我作为资深通讯作者和首席研究员的第一篇论文, so that means a lot to me personally,白说。. “作为教授,欧亚体育可以组成一个团队,做出一些可发表的东西,这是一种激励. 它给了欧亚体育信心,让欧亚体育可以把欧亚体育的热情付诸行动,展示欧亚体育的想法,产生影响.”

与北卡罗来纳大学医学院的合作为吴斌和他的团队提供了他们所需要的洞察力,以确定他们是否可以使用目前的实验室技术来创造解决方案, 或者他们是否应该探索额外的技术来解决他们面临的挑战.

“与APS之外的不同研究领域的联系极大地造福了团队和工作,白说。. “Col实验室orating with the clinical doctors at the medical school was huge. 合作非常顺利和轻松,我被团队的热情所震撼.”

作为一名大学生, graduate and postdoc re欧亚体育er, 白有与多学科团队合作的丰富经验. Today, he incorporates that same approach into his 实验室 with his students.

“有时, 即使是来自完全不同领域的研究人员的一个很小的和无意的建议,也可以节省几个月的时间来寻找绕过技术障碍的方法,白说. “Col实验室orating with UNC medical experts, especially doctors on the front line, 帮助欧亚体育更多地了解他们使用现有医疗器械的个人经验,以及欧亚体育可能面临的潜在挑战.”

Bai is working with Innovate Carolina’s Office of Technology Commercialization to move the technology forward, and the team has a provisional patent filed associated with the paper. OTC有助于加速将重要思想转化为有利于北卡罗来纳州的有意义的产品和服务, the world and the University. 白希望这项技术能在不久的将来得到应用,以解决整体未满足的医疗需求和挑战.